Assay Detail
Binding
CHEMBL817089
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Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships of novel vasopressin antagonists containing C-terminal diaminoalkanes and (aminoalkyl)guanidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.12 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2370646 | — | — | 1 | 8.36 |
| CHEMBL2370642 | — | — | 1 | 8.33 |
| CHEMBL2370640 | — | — | 1 | 8.25 |
| CHEMBL416114 | — | — | 1 | 8.24 |
| CHEMBL265591 | — | — | 1 | 8.22 |
| CHEMBL409667 | — | — | 1 | 8.08 |
| CHEMBL3037878 | — | — | 1 | 8.03 |
| CHEMBL2370641 | — | — | 1 | 8.00 |
| CHEMBL437674 | — | — | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2370646 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL2370642 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL2370640 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL416114 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL265591 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL409667 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL3037878 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL2370641 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL437674 | — | Ki | = | 28.0 | nM | 7.55 |