Assay Detail
Binding
CHEMBL817093
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Half-maximal inhibition of binding of [3H]- vasopressin to the vasopressin receptor 2 in rat kidney
83
Total Activities
83
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Kidney |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Orally active, nonpeptide oxytocin antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 83 | 4.43 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL125847 | — | — | 1 | 5.00 |
| CHEMBL340237 | — | — | 1 | 5.00 |
| CHEMBL126999 | — | — | 1 | 4.52 |
| CHEMBL339681 | — | — | 1 | 4.08 |
| CHEMBL341490 | — | — | 1 | 4.00 |
| CHEMBL127117 | — | — | 1 | 4.00 |
| CHEMBL129268 | — | — | 1 | - |
| CHEMBL340581 | — | — | 1 | - |
| CHEMBL341108 | — | — | 1 | - |
| CHEMBL339302 | — | — | 1 | - |
| CHEMBL126773 | — | — | 1 | - |
| CHEMBL127049 | — | — | 1 | - |
| CHEMBL128978 | — | — | 1 | - |
| CHEMBL129498 | — | — | 1 | - |
| CHEMBL126709 | — | — | 1 | - |
| CHEMBL340920 | — | — | 1 | - |
| CHEMBL127063 | — | — | 1 | - |
| CHEMBL126025 | — | — | 1 | - |
| CHEMBL337959 | — | — | 1 | - |
| CHEMBL340102 | — | — | 1 | - |
| CHEMBL407977 | — | — | 1 | - |
| CHEMBL126951 | — | — | 1 | - |
| CHEMBL341119 | — | — | 1 | - |
| CHEMBL129581 | — | — | 1 | - |
| CHEMBL338757 | — | — | 1 | - |
| CHEMBL338318 | — | — | 1 | - |
| CHEMBL340531 | — | — | 1 | - |
| CHEMBL341095 | — | — | 1 | - |
| CHEMBL126883 | — | — | 1 | - |
| CHEMBL341077 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL125847 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL340237 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL126999 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL339681 | — | IC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL341490 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL127117 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL130186 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL126025 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL129513 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL127957 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL126785 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL126962 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL341482 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL125350 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL129031 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL340581 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL340588 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL338470 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL340465 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL338336 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL126232 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL339472 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL129647 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL125343 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL130695 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL341267 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL126371 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL127016 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL340102 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL341077 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL126883 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL341095 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL340531 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL338318 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL338757 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL129581 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL341119 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL126951 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL407977 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL127063 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL337959 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL129268 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL341108 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL339302 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL126773 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL127049 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL128978 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL129498 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL126709 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL340920 | — | IC50 | > | 100000.0 | nM | - |