Assay Detail
Functional
CHEMBL817162
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for inhibitory activity against a multi drug resistant (MDR) strain of human colon carcinoma WiDr using sulforhodamine B assay (it is MRP positive but non-P-glycoprotein).
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | WiDr |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Analogues of amonafide and azonafide with novel ring systems.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.34 | 7.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290677 | AZONAFIDE | — | 1 | 7.03 |
| CHEMBL318380 | — | — | 1 | 6.96 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.89 |
| CHEMBL318355 | — | — | 1 | 6.76 |
| CHEMBL324189 | — | — | 1 | 6.71 |
| CHEMBL105615 | — | — | 1 | 6.68 |
| CHEMBL105650 | — | — | 1 | 6.66 |
| CHEMBL106541 | — | — | 1 | 6.62 |
| CHEMBL105801 | — | — | 1 | 6.58 |
| CHEMBL319702 | — | — | 1 | 6.43 |
| CHEMBL105797 | — | — | 1 | 6.42 |
| CHEMBL105266 | — | — | 1 | 6.38 |
| CHEMBL321274 | — | — | 1 | 6.35 |
| CHEMBL107783 | — | — | 1 | 6.34 |
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 6.31 |
| CHEMBL105503 | — | — | 1 | 6.30 |
| CHEMBL104820 | — | — | 1 | 6.28 |
| CHEMBL319187 | — | — | 1 | 6.10 |
| CHEMBL105035 | — | — | 1 | 5.89 |
| CHEMBL105277 | — | — | 1 | 5.82 |
| CHEMBL321071 | — | — | 1 | 5.80 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 5.66 |
| CHEMBL105443 | — | — | 1 | 5.64 |
| CHEMBL323455 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290677 | AZONAFIDE | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL318380 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL318355 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL324189 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL105615 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL105650 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL106541 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL105801 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL319702 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL105797 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL105266 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL321274 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL107783 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL58 | MITOXANTRONE | IC50 | = | 488.0 | nM | 6.31 |
| CHEMBL105503 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL104820 | — | IC50 | = | 525.0 | nM | 6.28 |
| CHEMBL319187 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL105035 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL105277 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL321071 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL105443 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL323455 | — | IC50 | = | 2400.0 | nM | 5.62 |