Assay Detail
Functional
CHEMBL817256
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Cytotoxicity in a growth inhibition assay against aerobic cultures of UV4 cells was determined
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | UV4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Reductive chemistry of the novel hypoxia-selective cytotoxin 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.90 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL277882 | — | — | 1 | 7.54 |
| CHEMBL280898 | — | — | 1 | 6.66 |
| CHEMBL21319 | — | — | 1 | 6.06 |
| CHEMBL21048 | — | — | 1 | 4.92 |
| CHEMBL20569 | — | — | 1 | 4.31 |
| CHEMBL283558 | — | — | 1 | - |
| CHEMBL281812 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL277882 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL280898 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL21319 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL21048 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL20569 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL283558 | — | IC50 | = | 3000000.0 | nM | - |
| CHEMBL281812 | — | IC50 | = | 960000.0 | nM | - |