Assay Detail
Binding
CHEMBL817281
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Compound was evaluated to inhibit the trypsin enzyme
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
C6 modification of the pyridinone core of thrombin inhibitor L-374,087 as a means of enhancing its oral absorption.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.52 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45480 | — | — | 1 | 5.85 |
| CHEMBL431535 | — | — | 1 | 5.77 |
| CHEMBL49457 | — | — | 1 | 5.72 |
| CHEMBL46331 | — | — | 1 | 5.60 |
| CHEMBL47920 | — | — | 1 | 5.58 |
| CHEMBL11157 | L-374087 | — | 1 | 5.50 |
| CHEMBL46135 | — | — | 1 | 5.47 |
| CHEMBL48929 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45480 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL431535 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL49457 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL46331 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL47920 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL11157 | L-374087 | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL46135 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL48929 | — | Ki | = | 20000.0 | nM | 4.70 |