Assay Detail
Binding
CHEMBL817288
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Inhibitory activity of compound against human tryptase was determined
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis of potent and highly selective nonguanidine azetidinone inhibitors of human tryptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.22 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70350 | — | — | 1 | 9.00 |
| CHEMBL306448 | — | — | 1 | 8.74 |
| CHEMBL302058 | — | — | 1 | 8.40 |
| CHEMBL71037 | — | — | 1 | 8.40 |
| CHEMBL441447 | — | — | 1 | 8.15 |
| CHEMBL306696 | — | — | 1 | 7.72 |
| CHEMBL72279 | — | — | 1 | 7.54 |
| CHEMBL308109 | — | — | 1 | 7.52 |
| CHEMBL70529 | — | — | 1 | 7.50 |
| CHEMBL70666 | — | — | 1 | 7.47 |
| CHEMBL70964 | — | — | 1 | 7.41 |
| CHEMBL422412 | — | — | 1 | 7.21 |
| CHEMBL305950 | — | — | 1 | 6.83 |
| CHEMBL430999 | — | — | 1 | 6.68 |
| CHEMBL307089 | — | — | 1 | 6.29 |
| CHEMBL70619 | — | — | 1 | 5.98 |
| CHEMBL273331 | — | — | 1 | 5.92 |
| CHEMBL308015 | — | — | 1 | 5.58 |
| CHEMBL70665 | — | — | 1 | 4.75 |
| CHEMBL72282 | — | — | 1 | - |
| CHEMBL303437 | — | — | 1 | - |
| CHEMBL70738 | — | — | 1 | - |
| CHEMBL303827 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70350 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL306448 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL302058 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL71037 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL441447 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL306696 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL72279 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL308109 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL70529 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL70666 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL70964 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL422412 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL305950 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL430999 | — | IC50 | = | 211.0 | nM | 6.68 |
| CHEMBL307089 | — | IC50 | = | 515.0 | nM | 6.29 |
| CHEMBL70619 | — | IC50 | = | 1053.0 | nM | 5.98 |
| CHEMBL273331 | — | IC50 | = | 1214.0 | nM | 5.92 |
| CHEMBL308015 | — | IC50 | = | 2605.0 | nM | 5.58 |
| CHEMBL70665 | — | IC50 | = | 17899.0 | nM | 4.75 |
| CHEMBL72282 | — | IC50 | < | 1.7 | nM | - |
| CHEMBL303437 | — | IC50 | < | 1.7 | nM | - |
| CHEMBL70738 | — | IC50 | < | 1.7 | nM | - |
| CHEMBL303827 | — | IC50 | > | 33000.0 | nM | - |