Assay Detail
Binding
CHEMBL817294
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Tryptase in human mast cells
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Dibasic inhibitors of human mast cell tryptase. Part 3: identification of a series of potent and selective inhibitors containing the benzamidine functionality.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 8.18 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL46809 | — | — | 1 | 10.15 |
| CHEMBL297220 | — | — | 1 | 9.40 |
| CHEMBL42900 | — | — | 1 | 9.30 |
| CHEMBL43938 | — | — | 1 | 9.07 |
| CHEMBL40491 | — | — | 1 | 9.04 |
| CHEMBL42898 | — | — | 1 | 8.95 |
| CHEMBL38054 | — | — | 1 | 8.17 |
| CHEMBL298256 | — | — | 1 | 8.06 |
| CHEMBL295007 | — | — | 1 | 8.05 |
| CHEMBL42899 | — | — | 1 | 7.80 |
| CHEMBL295450 | — | — | 1 | 7.79 |
| CHEMBL296733 | — | — | 1 | 7.62 |
| CHEMBL42037 | — | — | 1 | 7.55 |
| CHEMBL42364 | — | — | 1 | 7.39 |
| CHEMBL406192 | — | — | 1 | 6.96 |
| CHEMBL289918 | — | — | 1 | 6.95 |
| CHEMBL297408 | — | — | 1 | 6.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL46809 | — | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL297220 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL42900 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL43938 | — | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL40491 | — | Ki | = | 0.91 | nM | 9.04 |
| CHEMBL42898 | — | Ki | = | 1.12 | nM | 8.95 |
| CHEMBL38054 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL298256 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL295007 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL42899 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL295450 | — | Ki | = | 16.4 | nM | 7.79 |
| CHEMBL296733 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL42037 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL42364 | — | Ki | = | 40.6 | nM | 7.39 |
| CHEMBL406192 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL289918 | — | Ki | = | 112.0 | nM | 6.95 |
| CHEMBL297408 | — | Ki | = | 155.0 | nM | 6.81 |