Assay Detail
Binding
CHEMBL817298
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Inhibitory concentration against human tryptase
16
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis of potent and highly selective inhibitors of human tryptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.91 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109504 | — | — | 1 | 8.72 |
| CHEMBL71037 | — | — | 1 | 8.40 |
| CHEMBL302058 | — | — | 1 | 8.40 |
| CHEMBL447534 | — | — | 1 | 8.34 |
| CHEMBL113591 | — | — | 1 | 8.22 |
| CHEMBL432835 | — | — | 1 | 8.05 |
| CHEMBL109733 | — | — | 1 | 7.92 |
| CHEMBL324621 | — | — | 3 | 7.20 |
| CHEMBL303437 | — | — | 1 | - |
| CHEMBL326209 | — | — | 1 | - |
| CHEMBL111630 | — | — | 1 | - |
| CHEMBL111173 | — | — | 1 | - |
| CHEMBL70738 | — | — | 1 | - |
| CHEMBL440515 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109504 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL71037 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL302058 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL447534 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL113591 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL432835 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL109733 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL324621 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL324621 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL324621 | — | IC50 | = | 204.0 | nM | 6.69 |
| CHEMBL303437 | — | IC50 | < | 1.7 | nM | - |
| CHEMBL326209 | — | IC50 | < | 1.7 | nM | - |
| CHEMBL111630 | — | IC50 | < | 1.7 | nM | - |
| CHEMBL111173 | — | IC50 | < | 1.7 | nM | - |
| CHEMBL70738 | — | IC50 | < | 1.7 | nM | - |
| CHEMBL440515 | — | IC50 | < | 1.7 | nM | - |