Assay Detail
Binding
CHEMBL817420
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In vitro activity against mammalian topoisomerase II measured as ATP-dependent unknotting of P4 DNA compared to enzyme and DNA control
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Antitumor agents. 185. Synthesis and biological evaluation of tridemethylthiocolchicine analogues as novel topoisomerase II inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.63 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61609 | — | — | 1 | 5.05 |
| CHEMBL301851 | — | — | 1 | 4.42 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 4.42 |
| CHEMBL61573 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61609 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL301851 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL61573 | — | IC50 | > | 150000.0 | nM | - |