Assay Detail
Functional
CHEMBL817597
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for influx of calcium mobilization in human U937 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Development of new chromanol antagonists of leukotriene D4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.15 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL21333 | PRANLUKAST | 4.0 | 1 | 9.00 |
| CHEMBL603 | ZAFIRLUKAST | 4.0 | 1 | 9.00 |
| CHEMBL300701 | — | — | 1 | 8.10 |
| CHEMBL442150 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL21333 | PRANLUKAST | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL603 | ZAFIRLUKAST | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL300701 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL442150 | — | IC50 | = | 310.0 | nM | 6.51 |