Assay Detail
Binding
CHEMBL817701
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Compound was evaluated for the competitive inhibition of trypanothione reduction by recombinant Trypanothione reductase from Trypanosoma cruzi
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel polyamine derivatives as potent competitive inhibitors of Trypanosoma cruzi trypanothione reductase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.13 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62048 | — | — | 1 | 5.46 |
| CHEMBL61691 | — | — | 1 | 5.26 |
| CHEMBL415 | CLOMIPRAMINE | 4.0 | 1 | 5.19 |
| CHEMBL305575 | — | — | 1 | 5.02 |
| CHEMBL58084 | — | — | 1 | 4.72 |
| CHEMBL58301 | — | — | 1 | - |
| CHEMBL298628 | — | — | 1 | - |
| CHEMBL418644 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62048 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL61691 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL415 | CLOMIPRAMINE | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL305575 | — | Ki | = | 9500.0 | nM | 5.02 |
| CHEMBL58084 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL58301 | — | Ki | > | 2000000.0 | nM | - |
| CHEMBL298628 | — | Ki | = | 108000.0 | nM | - |
| CHEMBL418644 | — | Ki | = | 280000.0 | nM | - |