Assay Detail
Binding
CHEMBL817776
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Inhibition of TNF-alpha binding to TNFRc1
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Tumor necrosis factor receptor superfamily member 1A (CHEMBL3378) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Both 5-arylidene-2-thioxodihydropyrimidine-4,6(1H,5H)-diones and 3-thioxo-2,3-dihydro-1H-imidazo[1,5-a]indol-1-ones are light-dependent tumor necrosis factor-alpha antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.93 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL359346 | — | — | 1 | 6.89 |
| CHEMBL357092 | — | — | 1 | 6.85 |
| CHEMBL150292 | — | — | 1 | 6.68 |
| CHEMBL356012 | — | — | 1 | 6.68 |
| CHEMBL356830 | — | — | 1 | 6.55 |
| CHEMBL151203 | — | — | 1 | 6.55 |
| CHEMBL150886 | — | — | 1 | 6.52 |
| CHEMBL423208 | — | — | 1 | 6.51 |
| CHEMBL146955 | — | — | 1 | 6.50 |
| CHEMBL151686 | — | — | 1 | 6.41 |
| CHEMBL150992 | — | — | 1 | 6.40 |
| CHEMBL359348 | — | — | 1 | 6.22 |
| CHEMBL345772 | — | — | 1 | 6.21 |
| CHEMBL355913 | — | — | 1 | 6.17 |
| CHEMBL151752 | — | — | 1 | 6.11 |
| CHEMBL347715 | — | — | 1 | 6.10 |
| CHEMBL345500 | — | — | 1 | 6.00 |
| CHEMBL151578 | — | — | 1 | 6.00 |
| CHEMBL345771 | — | — | 1 | 5.96 |
| CHEMBL150870 | — | — | 1 | 5.77 |
| CHEMBL147036 | — | — | 1 | 5.75 |
| CHEMBL149958 | — | — | 1 | 5.72 |
| CHEMBL151153 | — | — | 1 | 5.70 |
| CHEMBL151328 | — | — | 1 | 5.68 |
| CHEMBL149465 | — | — | 1 | 5.55 |
| CHEMBL151946 | — | — | 1 | 5.47 |
| CHEMBL151107 | — | — | 1 | 5.35 |
| CHEMBL357999 | — | — | 1 | 5.26 |
| CHEMBL150675 | — | — | 1 | 4.99 |
| CHEMBL356815 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL359346 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL357092 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL150292 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL356012 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL356830 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL151203 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL150886 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL423208 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL146955 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL151686 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL150992 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL359348 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL345772 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL355913 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL151752 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL347715 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL345500 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL151578 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL345771 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL150870 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL147036 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL149958 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL151153 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL151328 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL149465 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL151946 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL151107 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL357999 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL150675 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL356815 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL155504 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL150651 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL357328 | — | IC50 | = | 40000.0 | nM | 4.40 |