Assay Detail
Binding
CHEMBL817807
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Inhibition of trypsin in human plasma
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Small, low nanomolar, noncovalent thrombin inhibitors lacking a group to fill the 'distal binding pocket'.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 4.98 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431524 | — | — | 1 | 6.00 |
| CHEMBL19080 | L-375378 | — | 1 | 5.75 |
| CHEMBL296737 | — | — | 1 | 5.70 |
| CHEMBL43641 | — | — | 1 | 5.15 |
| CHEMBL46638 | — | — | 1 | 5.14 |
| CHEMBL45062 | — | — | 1 | 5.00 |
| CHEMBL44226 | — | — | 1 | 4.96 |
| CHEMBL43145 | — | — | 1 | 4.85 |
| CHEMBL44249 | — | — | 1 | 4.70 |
| CHEMBL296041 | — | — | 1 | 4.70 |
| CHEMBL42039 | — | — | 1 | 4.64 |
| CHEMBL44868 | — | — | 1 | 4.64 |
| CHEMBL42495 | — | — | 1 | 4.54 |
| CHEMBL42091 | — | — | 1 | 4.00 |
| CHEMBL42496 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431524 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL19080 | L-375378 | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL296737 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL43641 | — | Ki | = | 7100.0 | nM | 5.15 |
| CHEMBL46638 | — | Ki | = | 7200.0 | nM | 5.14 |
| CHEMBL45062 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL44226 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL43145 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL44249 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL296041 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL42039 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL44868 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL42495 | — | Ki | = | 29000.0 | nM | 4.54 |
| CHEMBL42091 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL42496 | — | Ki | > | 100000.0 | nM | - |