Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL817813

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against human trypsin
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Serine protease 1 (CHEMBL209)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Potent noncovalent thrombin inhibitors that utilize the unique amino acid D-dicyclohexylalanine in the P3 position. Implications on oral bioavailability and antithrombotic efficacy.
Tucker TJ, Lumma WC, Lewis SD, Gardell SJ, Lucas BJ, Baskin EP, Woltmann R, Lynch JJ, Lyle EA, Appleby SD, Chen IW, Dancheck KB, Vacca JP.
J Med Chem (1997) 40 : 1565 -1569
PubMed 9171866 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 7.03 7.03

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL416795 1 7.03

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL416795 Ki = 94.0 nM 7.03