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Assay Detail

CHEMBL817814

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Trypsin
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Serine protease 1 (CHEMBL209)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Azaindoles: moderately basic P1 groups for enhancing the selectivity of thrombin inhibitors.
Sanderson PE, Stanton MG, Dorsey BD, Lyle TA, McDonough C, Sanders WM, Savage KL, Naylor-Olsen AM, Krueger JA, Lewis SD, Lucas BJ, Lynch JJ, Yan Y.
Bioorg Med Chem Lett (2003) 13 : 795 -798
PubMed 12617893 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 5.16 5.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL19080 L-375378 1 5.75
CHEMBL101563 1 5.70
CHEMBL353213 1 5.17
CHEMBL167550 1 4.00
CHEMBL355730 1 -
CHEMBL166530 1 -
CHEMBL166602 1 -
CHEMBL422387 1 -
CHEMBL164924 1 -
CHEMBL168176 1 -
CHEMBL164333 1 -
CHEMBL355314 1 -
CHEMBL167755 1 -
CHEMBL167995 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL19080 L-375378 Ki = 1800.0 nM 5.75
CHEMBL101563 Ki = 2000.0 nM 5.70
CHEMBL353213 Ki = 6800.0 nM 5.17
CHEMBL167550 Ki = 100000.0 nM 4.00
CHEMBL355730 Ki = 290000.0 nM -
CHEMBL166530 Ki > 100000.0 nM -
CHEMBL166602 Ki = 120000.0 nM -
CHEMBL422387 Ki > 100000.0 nM -
CHEMBL164924 Ki > 100000.0 nM -
CHEMBL168176 Ki > 100000.0 nM -
CHEMBL164333 Ki > 1000000.0 nM -
CHEMBL355314 Ki = 200000.0 nM -
CHEMBL167755 Ki = 140000.0 nM -
CHEMBL167995 Ki > 100000.0 nM -