Assay Detail
Binding
CHEMBL817817
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Inhibitory activity against human trypsin
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of potent and selective macrocyclic thrombin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 5.79 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92615 | — | — | 1 | 7.40 |
| CHEMBL418965 | — | — | 1 | 7.10 |
| CHEMBL316901 | — | — | 1 | 7.05 |
| CHEMBL94952 | — | — | 1 | 6.96 |
| CHEMBL96354 | — | — | 1 | 6.96 |
| CHEMBL317393 | — | — | 1 | 6.62 |
| CHEMBL94864 | — | — | 1 | 6.24 |
| CHEMBL327421 | — | — | 1 | 5.68 |
| CHEMBL94413 | — | — | 1 | 5.40 |
| CHEMBL96599 | — | — | 1 | 5.34 |
| CHEMBL93315 | — | — | 1 | 5.30 |
| CHEMBL329266 | — | — | 1 | 5.17 |
| CHEMBL2204325 | — | — | 1 | 5.03 |
| CHEMBL96801 | — | — | 1 | 4.77 |
| CHEMBL94622 | — | — | 1 | 4.67 |
| CHEMBL329912 | — | — | 1 | 4.39 |
| CHEMBL96376 | — | — | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92615 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL418965 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL316901 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL94952 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL96354 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL317393 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL94864 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL327421 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL94413 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL96599 | — | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL93315 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL329266 | — | Ki | = | 6700.0 | nM | 5.17 |
| CHEMBL2204325 | — | Ki | = | 9300.0 | nM | 5.03 |
| CHEMBL96801 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL94622 | — | Ki | = | 21500.0 | nM | 4.67 |
| CHEMBL329912 | — | Ki | = | 41000.0 | nM | 4.39 |
| CHEMBL96376 | — | Ki | = | 48000.0 | nM | 4.32 |