Assay Detail
Binding
CHEMBL817818
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Inhibitory activity against trypsin was determined
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Efficacious, orally bioavailable thrombin inhibitors based on 3-aminopyridinone or 3-aminopyrazinone acetamide peptidomimetic templates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.70 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL138855 | — | — | 1 | 6.00 |
| CHEMBL139331 | — | — | 1 | 5.92 |
| CHEMBL336438 | — | — | 1 | 5.82 |
| CHEMBL19080 | L-375378 | — | 1 | 5.75 |
| CHEMBL140885 | — | — | 1 | 5.68 |
| CHEMBL141266 | — | — | 1 | 5.58 |
| CHEMBL11157 | L-374087 | — | 1 | 5.50 |
| CHEMBL139178 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL138855 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL139331 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL336438 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL19080 | L-375378 | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL140885 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL141266 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL11157 | L-374087 | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL139178 | — | Ki | = | 4800.0 | nM | 5.32 |