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Assay Detail

CHEMBL817823

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibition of human trypsin.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Serine protease 1 (CHEMBL209)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design of selective thrombin inhibitors based on the (R)-Phe-Pro-Arg sequence.
Danilewicz JC, Abel SM, Brown AD, Fish PV, Hawkeswood E, Holland SJ, James K, McElroy AB, Overington J, Powling MJ, Rance DJ.
J Med Chem (2002) 45 : 2432 -2453
PubMed 12036353 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 18 5.78 7.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL81056 1 7.05
CHEMBL309670 1 6.43
CHEMBL312647 1 6.26
CHEMBL309403 1 6.16
CHEMBL82658 1 6.14
CHEMBL84389 1 6.09
CHEMBL84229 1 5.96
CHEMBL418923 1 5.85
CHEMBL313788 1 5.80
CHEMBL81436 1 5.80
CHEMBL81521 1 5.71
CHEMBL82535 1 5.54
CHEMBL79442 1 5.32
CHEMBL81251 1 5.30
CHEMBL83280 1 5.30
CHEMBL81844 1 5.14
CHEMBL81643 1 5.10
CHEMBL312479 1 5.04

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL81056 Ki = 89.0 nM 7.05
CHEMBL309670 Ki = 370.0 nM 6.43
CHEMBL312647 Ki = 550.0 nM 6.26
CHEMBL309403 Ki = 700.0 nM 6.16
CHEMBL82658 Ki = 720.0 nM 6.14
CHEMBL84389 Ki = 810.0 nM 6.09
CHEMBL84229 Ki = 1100.0 nM 5.96
CHEMBL418923 Ki = 1400.0 nM 5.85
CHEMBL313788 Ki = 1600.0 nM 5.80
CHEMBL81436 Ki = 1600.0 nM 5.80
CHEMBL81521 Ki = 1930.0 nM 5.71
CHEMBL82535 Ki = 2900.0 nM 5.54
CHEMBL79442 Ki = 4800.0 nM 5.32
CHEMBL81251 Ki = 5000.0 nM 5.30
CHEMBL83280 Ki = 5000.0 nM 5.30
CHEMBL81844 Ki = 7300.0 nM 5.14
CHEMBL81643 Ki = 7900.0 nM 5.10
CHEMBL312479 Ki = 9200.0 nM 5.04