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Assay Detail

CHEMBL817828

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Binding
Binding to vesicular acetylcholine transporter of torpedo synaptic vesicles
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Torpedo
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Vesicular acetylcholine transporter (CHEMBL4767)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

N-hydroxyalkyl derivatives of 3 beta-phenyltropane and 1-methylspiro[1H-indoline-3,4'-piperidine]: vesamicol analogues with affinity for monoamine transporters.
Efange SM, Kamath AP, Khare AB, Kung MP, Mach RH, Parsons SM.
J Med Chem (1997) 40 : 3905 -3914
PubMed 9397171 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 34 7.49 10.26

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL87379 BENZOVESAMICOL 1 10.26
CHEMBL50880 1 9.89
CHEMBL87594 1 9.44
CHEMBL87414 1 9.44
CHEMBL129530 1 9.36
CHEMBL314170 1 9.17
CHEMBL20730 VESAMICOL 1 8.70
CHEMBL315146 1 8.12
CHEMBL125795 1 8.07
CHEMBL338411 1 8.07
CHEMBL339863 1 7.99
CHEMBL126762 1 7.84
CHEMBL340815 1 7.77
CHEMBL126479 1 7.52
CHEMBL126488 1 7.48
CHEMBL127013 1 7.22
CHEMBL127180 1 7.13
CHEMBL339491 1 7.11
CHEMBL340185 1 7.07
CHEMBL341139 1 7.07
CHEMBL337929 1 6.89
CHEMBL339281 1 6.84
CHEMBL89812 1 6.77
CHEMBL126257 1 6.74
CHEMBL127365 1 6.53
CHEMBL127790 1 6.49
CHEMBL129363 1 6.42
CHEMBL338469 1 6.39
CHEMBL338140 1 6.38
CHEMBL126742 1 6.32

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL87379 BENZOVESAMICOL Ki = 0.055 nM 10.26
CHEMBL50880 Ki = 0.13 nM 9.89
CHEMBL87594 Ki = 0.36 nM 9.44
CHEMBL87414 Ki = 0.36 nM 9.44
CHEMBL129530 Ki = 0.44 nM 9.36
CHEMBL314170 Ki = 0.67 nM 9.17
CHEMBL20730 VESAMICOL Ki = 2.0 nM 8.70
CHEMBL315146 Ki = 7.6 nM 8.12
CHEMBL125795 Ki = 8.5 nM 8.07
CHEMBL338411 Ki = 8.5 nM 8.07
CHEMBL339863 Ki = 10.3 nM 7.99
CHEMBL126762 Ki = 14.5 nM 7.84
CHEMBL340815 Ki = 17.0 nM 7.77
CHEMBL126479 Ki = 30.0 nM 7.52
CHEMBL126488 Ki = 33.0 nM 7.48
CHEMBL127013 Ki = 60.0 nM 7.22
CHEMBL127180 Ki = 74.0 nM 7.13
CHEMBL339491 Ki = 77.0 nM 7.11
CHEMBL340185 Ki = 86.0 nM 7.07
CHEMBL341139 Ki = 85.0 nM 7.07
CHEMBL337929 Ki = 130.0 nM 6.89
CHEMBL339281 Ki = 144.0 nM 6.84
CHEMBL89812 Ki = 170.0 nM 6.77
CHEMBL126257 Ki = 182.0 nM 6.74
CHEMBL127365 Ki = 298.0 nM 6.53
CHEMBL127790 Ki = 325.0 nM 6.49
CHEMBL129363 Ki = 380.11 nM 6.42
CHEMBL338469 Ki = 411.0 nM 6.39
CHEMBL338140 Ki = 420.0 nM 6.38
CHEMBL126742 Ki = 474.0 nM 6.32
CHEMBL405524 Ki = 570.0 nM 6.24
CHEMBL340816 Ki = 594.0 nM 6.23
CHEMBL126019 Ki = 600.0 nM 6.22
CHEMBL339712 Ki = 3400.0 nM 5.47