Assay Detail
Binding
CHEMBL817834
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against human Vasopressin V2 receptor expressed in HeLa cells was determined
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HeLa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Characterization of orally active nonpeptide vasopressin V(2) receptor agonist. Synthesis and biological evaluation of both the (5R)- and (5S)-enantioisomers of 2-[1-(2-Chloro-4-pyrrolidin-1-yl-benzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepin- 5-yl]-N-isopropylacetamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.85 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL340893 | — | — | 1 | 8.05 |
| CHEMBL332447 | — | — | 1 | 6.48 |
| CHEMBL125878 | — | — | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL340893 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL332447 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL125878 | — | IC50 | = | 980.0 | nM | 6.01 |