Assay Detail
Binding
CHEMBL817841
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Inhibition of [3H]AVP binding to human Vasopressin V2 receptor expressed in HeLa cells
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HeLa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel design of nonpeptide AVP V(2) receptor agonists: structural requirements for an agonist having 1-(4-aminobenzoyl)-2,3,4, 5-tetrahydro-1H-1-benzazepine as a template.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.55 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL334376 | — | — | 1 | 8.39 |
| CHEMBL343945 | — | — | 1 | 8.30 |
| CHEMBL136644 | — | — | 1 | 8.23 |
| CHEMBL342250 | — | — | 1 | 8.12 |
| CHEMBL139863 | — | — | 1 | 8.06 |
| CHEMBL340893 | — | — | 1 | 8.05 |
| CHEMBL136109 | — | — | 1 | 7.89 |
| CHEMBL335592 | — | — | 1 | 7.89 |
| CHEMBL136628 | — | — | 1 | 7.80 |
| CHEMBL136177 | — | — | 1 | 7.75 |
| CHEMBL343935 | — | — | 1 | 7.75 |
| CHEMBL334688 | — | — | 1 | 7.72 |
| CHEMBL139415 | — | — | 1 | 7.66 |
| CHEMBL137500 | — | — | 1 | 7.51 |
| CHEMBL134525 | — | — | 1 | 7.47 |
| CHEMBL337098 | — | — | 1 | 7.46 |
| CHEMBL136790 | — | — | 1 | 7.29 |
| CHEMBL136065 | — | — | 1 | 6.92 |
| CHEMBL344848 | — | — | 1 | 6.75 |
| CHEMBL335040 | — | — | 1 | 6.68 |
| CHEMBL342251 | — | — | 1 | 6.50 |
| CHEMBL343538 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL334376 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL343945 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL136644 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL342250 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL139863 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL340893 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL136109 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL335592 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL136628 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL136177 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL343935 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL334688 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL139415 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL137500 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL134525 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL337098 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL136790 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL136065 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL344848 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL335040 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL342251 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL343538 | — | IC50 | = | 1000.0 | nM | 6.00 |