Assay Detail
Binding
CHEMBL817892
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Inhibitory activity against trypsin
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.11 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71037 | — | — | 1 | 8.35 |
| CHEMBL70155 | — | — | 1 | 7.21 |
| CHEMBL70350 | — | — | 1 | 6.51 |
| CHEMBL69394 | — | — | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71037 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL70155 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL70350 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL69394 | — | IC50 | = | 440.0 | nM | 6.36 |