Assay Detail
Binding
CHEMBL818017
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory constant evaluated against trypsin
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Unexpected enhancement of thrombin inhibitor potency with o-aminoalkylbenzylamides in the P1 position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 5.25 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL419773 | — | — | 1 | 6.38 |
| CHEMBL287614 | — | — | 1 | 6.24 |
| CHEMBL115755 | — | — | 1 | 5.89 |
| CHEMBL116258 | — | — | 1 | 5.80 |
| CHEMBL19080 | L-375378 | — | 1 | 5.75 |
| CHEMBL420682 | — | — | 1 | 5.73 |
| CHEMBL115643 | — | — | 1 | 5.52 |
| CHEMBL11157 | L-374087 | — | 1 | 5.50 |
| CHEMBL117098 | — | — | 1 | 5.21 |
| CHEMBL119820 | — | — | 1 | 5.20 |
| CHEMBL334257 | — | — | 1 | 4.85 |
| CHEMBL296041 | — | — | 1 | 4.70 |
| CHEMBL117147 | — | — | 1 | 4.64 |
| CHEMBL116202 | — | — | 1 | 4.43 |
| CHEMBL116015 | — | — | 1 | 4.17 |
| CHEMBL321130 | — | — | 1 | 4.05 |
| CHEMBL117365 | — | — | 1 | - |
| CHEMBL117387 | — | — | 1 | - |
| CHEMBL324349 | — | — | 1 | - |
| CHEMBL119779 | — | — | 1 | - |
| CHEMBL116597 | — | — | 1 | - |
| CHEMBL118077 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL419773 | — | Ki | = | 415.0 | nM | 6.38 |
| CHEMBL287614 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL115755 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL116258 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL19080 | L-375378 | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL420682 | — | Ki | = | 1850.0 | nM | 5.73 |
| CHEMBL115643 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL11157 | L-374087 | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL117098 | — | Ki | = | 6200.0 | nM | 5.21 |
| CHEMBL119820 | — | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL334257 | — | Ki | = | 14200.0 | nM | 4.85 |
| CHEMBL296041 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL117147 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL116202 | — | Ki | = | 37000.0 | nM | 4.43 |
| CHEMBL116015 | — | Ki | = | 67000.0 | nM | 4.17 |
| CHEMBL321130 | — | Ki | = | 89000.0 | nM | 4.05 |
| CHEMBL117365 | — | Ki | = | 466000.0 | nM | - |
| CHEMBL117387 | — | Ki | = | 437000.0 | nM | - |
| CHEMBL324349 | — | Ki | = | 106000.0 | nM | - |
| CHEMBL119779 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL116597 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL118077 | — | Ki | = | 252000.0 | nM | - |