Assay Detail
Binding
CHEMBL818047
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Inhibition of [125I]VCAM-Ig binding to VLA-4 of Jurkat cells in the presence of [Ca2+]
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-isonicotinoyl-(L)-4-aminophenylalanine derivatives as tight binding VLA-4 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 9.84 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296804 | — | — | 1 | 10.15 |
| CHEMBL293807 | — | — | 1 | 10.10 |
| CHEMBL56822 | — | — | 1 | 10.10 |
| CHEMBL56511 | — | — | 1 | 10.05 |
| CHEMBL292619 | — | — | 1 | 10.05 |
| CHEMBL298835 | — | — | 1 | 10.00 |
| CHEMBL56520 | — | — | 1 | 10.00 |
| CHEMBL294708 | — | — | 1 | 9.96 |
| CHEMBL59531 | — | — | 1 | 9.89 |
| CHEMBL440481 | — | — | 1 | 9.82 |
| CHEMBL293756 | — | — | 1 | 9.68 |
| CHEMBL53733 | — | — | 1 | 9.60 |
| CHEMBL55900 | — | — | 1 | 9.51 |
| CHEMBL1160252 | — | — | 1 | 8.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296804 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL293807 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL56822 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL56511 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL292619 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL298835 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL56520 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL294708 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL59531 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL440481 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL293756 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL53733 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL55900 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL1160252 | — | IC50 | = | 1.56 | nM | 8.81 |