Assay Detail
Binding
CHEMBL818116
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Concentration required for inhibition of Trypanothione reductase (TcTR) from Trypanosoma cruzi in the presence of 50 uM TS2 as substrate
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Parallel synthesis of a library of 1,4-naphthoquinones and automated screening of potential inhibitors of trypanothione reductase from Trypanosoma cruzi.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.64 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160637 | — | — | 1 | 6.52 |
| CHEMBL358636 | — | — | 1 | 6.30 |
| CHEMBL159006 | — | — | 1 | 6.22 |
| CHEMBL155801 | — | — | 1 | 5.96 |
| CHEMBL295316 | PLUMBAGIN | 1.0 | 1 | 4.55 |
| CHEMBL590 | MENADIONE | 4.0 | 1 | 4.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160637 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL358636 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL159006 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL155801 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL295316 | PLUMBAGIN | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL590 | MENADIONE | IC50 | = | 55000.0 | nM | 4.26 |