Assay Detail
Binding
CHEMBL818145
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Escherichia coli Translocase (mraY)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Phospho-N-acetylmuramoyl-pentapeptide-transferase (CHEMBL3957) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli K-12 |
Publication
Synthesis of analogues of the O-beta-D-ribofuranosyl nucleoside moiety of liposidomycins. Part 1: contribution of the amino group and the uracil moiety upon the inhibition of MraY.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.61 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL355959 | — | — | 1 | 5.30 |
| CHEMBL151076 | — | — | 1 | 4.60 |
| CHEMBL147455 | — | — | 1 | 4.52 |
| CHEMBL357505 | — | — | 1 | 4.35 |
| CHEMBL20130 | — | — | 1 | 4.30 |
| CHEMBL423767 | — | — | 1 | - |
| CHEMBL151058 | — | — | 1 | - |
| CHEMBL151398 | — | — | 1 | - |
| CHEMBL357228 | — | — | 1 | - |
| CHEMBL151269 | — | — | 1 | - |
| CHEMBL435834 | — | — | 1 | - |
| CHEMBL151393 | — | — | 1 | - |
| CHEMBL434501 | — | — | 1 | - |
| CHEMBL147408 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL355959 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL151076 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL147455 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL357505 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL20130 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL423767 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL151058 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL151398 | — | IC50 | = | 140000.0 | nM | - |
| CHEMBL357228 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL151269 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL435834 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL151393 | — | IC50 | = | 180000.0 | nM | - |
| CHEMBL434501 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL147408 | — | IC50 | = | 150000.0 | nM | - |