Assay Detail
Binding
CHEMBL818148
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Inhibitory activity against translocase (Mra Y) obtained from bacteria.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of analogues of the O-beta-D-ribofuranosyl nucleoside moiety of liposidomycins. Part 2: role of the hydroxyl groups upon the inhibition of MraY.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.68 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL277069 | — | — | 1 | 5.30 |
| CHEMBL151287 | — | — | 1 | 5.00 |
| CHEMBL20130 | — | — | 1 | 4.30 |
| CHEMBL149413 | — | — | 1 | 4.10 |
| CHEMBL150030 | — | — | 1 | - |
| CHEMBL347962 | — | — | 1 | - |
| CHEMBL151583 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL277069 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL151287 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL20130 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL149413 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL150030 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL347962 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL151583 | — | IC50 | = | 115000.0 | nM | - |