Assay Detail
Binding
CHEMBL818149
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Inhibitory activity against Translocase I
58
Total Activities
58
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of sub-micromolar inhibitors of MraY by exploring the region originally occupied by the diazepanone ring in the liposidomycin structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 58 | 5.97 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3143227 | — | — | 1 | 7.19 |
| CHEMBL279892 | — | — | 1 | 6.85 |
| CHEMBL278312 | — | — | 1 | 6.80 |
| CHEMBL279208 | — | — | 1 | 6.77 |
| CHEMBL279474 | — | — | 1 | 6.77 |
| CHEMBL279080 | — | — | 1 | 6.75 |
| CHEMBL279473 | — | — | 1 | 6.70 |
| CHEMBL278626 | — | — | 1 | 6.70 |
| CHEMBL19519 | — | — | 1 | 6.66 |
| CHEMBL19321 | — | — | 1 | 6.64 |
| CHEMBL277025 | — | — | 1 | 6.60 |
| CHEMBL19791 | — | — | 1 | 6.52 |
| CHEMBL277170 | — | — | 1 | 6.51 |
| CHEMBL19500 | — | — | 1 | 6.51 |
| CHEMBL19510 | — | — | 1 | 6.50 |
| CHEMBL276299 | — | — | 1 | 6.48 |
| CHEMBL280960 | — | — | 1 | 6.46 |
| CHEMBL19608 | — | — | 1 | 6.41 |
| CHEMBL19782 | — | — | 1 | 6.40 |
| CHEMBL19725 | — | — | 1 | 6.37 |
| CHEMBL277844 | — | — | 1 | 6.36 |
| CHEMBL280909 | — | — | 1 | 6.36 |
| CHEMBL505513 | TUNICAMYCIN | — | 1 | 6.32 |
| CHEMBL283773 | — | — | 1 | 6.24 |
| CHEMBL278793 | — | — | 1 | 6.23 |
| CHEMBL278082 | — | — | 1 | 6.21 |
| CHEMBL278372 | — | — | 1 | 6.16 |
| CHEMBL416179 | — | — | 1 | 6.13 |
| CHEMBL17882 | — | — | 1 | 6.09 |
| CHEMBL277843 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3143227 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL279892 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL278312 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL279208 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL279474 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL279080 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL279473 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL278626 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL19519 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL19321 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL277025 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL19791 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL277170 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL19500 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL19510 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL276299 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL280960 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL19608 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL19782 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL19725 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL277844 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL280909 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL505513 | TUNICAMYCIN | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL283773 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL278793 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL278082 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL278372 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL416179 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL17882 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL277843 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL20146 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL19882 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL19546 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL429384 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL278563 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL277704 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL442108 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL20687 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL19602 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL278564 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL280394 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL280921 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL278821 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL282690 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL408813 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL19872 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL283536 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL19475 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL277069 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1202103 | — | IC50 | = | 5300.0 | nM | 5.28 |