Assay Detail
Binding
CHEMBL818162
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Inhibition of VLA-4 to VCAM-1 binding in Jurkat cell adhesion assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Dehydrophenylalanine derivatives as VLA-4 integrin antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.87 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2110195 | — | — | 1 | 8.43 |
| CHEMBL167852 | — | — | 1 | 7.60 |
| CHEMBL167240 | — | — | 1 | 7.16 |
| CHEMBL166477 | — | — | 1 | 7.10 |
| CHEMBL165936 | — | — | 1 | 6.85 |
| CHEMBL167007 | — | — | 1 | 6.70 |
| CHEMBL166656 | — | — | 1 | 6.39 |
| CHEMBL166418 | — | — | 1 | 5.30 |
| CHEMBL170110 | — | — | 1 | 5.15 |
| CHEMBL167239 | — | — | 1 | 5.07 |
| CHEMBL167961 | — | — | 1 | 4.85 |
| CHEMBL354087 | — | — | 1 | 4.70 |
| CHEMBL166878 | — | — | 1 | 4.54 |
| CHEMBL354719 | — | — | 1 | 4.15 |
| CHEMBL169095 | — | — | 1 | 4.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2110195 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL167852 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL167240 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL166477 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL165936 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL167007 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL166656 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL166418 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL170110 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL167239 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL167961 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL354087 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL166878 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL354719 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL169095 | — | IC50 | = | 83000.0 | nM | 4.08 |