Assay Detail
Binding
CHEMBL818172
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Inhibitory concentration required against trypsin was determined
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
The design of potent and selective inhibitors of thrombin utilizing a piperazinedione template: part 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.17 | 7.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL313790 | — | — | 1 | 7.02 |
| CHEMBL256219 | — | — | 1 | 6.47 |
| CHEMBL310722 | — | — | 1 | 5.64 |
| CHEMBL83001 | — | — | 1 | 5.43 |
| CHEMBL433144 | — | — | 1 | 5.39 |
| CHEMBL84084 | — | — | 1 | 5.32 |
| CHEMBL315086 | — | — | 1 | 5.32 |
| CHEMBL314462 | — | — | 1 | 5.16 |
| CHEMBL312904 | — | — | 1 | 5.14 |
| CHEMBL313769 | — | — | 1 | 5.11 |
| CHEMBL80013 | — | — | 1 | 5.07 |
| CHEMBL82753 | — | — | 1 | 5.06 |
| CHEMBL404654 | — | — | 1 | 5.04 |
| CHEMBL312151 | — | — | 1 | 5.04 |
| CHEMBL83260 | — | — | 1 | 5.01 |
| CHEMBL79245 | — | — | 1 | 4.96 |
| CHEMBL84536 | — | — | 1 | 4.85 |
| CHEMBL309298 | — | — | 1 | 4.82 |
| CHEMBL83692 | — | — | 1 | 4.77 |
| CHEMBL408553 | — | — | 1 | 4.74 |
| CHEMBL84083 | — | — | 1 | 4.68 |
| CHEMBL420589 | — | — | 1 | 4.60 |
| CHEMBL314791 | — | — | 1 | 4.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL313790 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL256219 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL310722 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL83001 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL433144 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL84084 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL315086 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL314462 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL312904 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL313769 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL80013 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL82753 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL404654 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL312151 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL83260 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL79245 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL84536 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL309298 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL83692 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL408553 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL84083 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL420589 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL314791 | — | IC50 | = | 45000.0 | nM | 4.35 |