Assay Detail
Binding
CHEMBL818183
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Binding affinity against trypsin in an enzyme inhibition assay.
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Preparation of pyrrolidine and isoxazolidine benzamidines as potent inhibitors of coagulation factor Xa.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.85 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18225 | — | — | 2 | 7.28 |
| CHEMBL279267 | — | — | 1 | 7.16 |
| CHEMBL18578 | — | — | 1 | 7.03 |
| CHEMBL276782 | — | — | 1 | 7.01 |
| CHEMBL429068 | — | — | 1 | 6.96 |
| CHEMBL277994 | — | — | 1 | 6.70 |
| CHEMBL18627 | — | — | 1 | 6.70 |
| CHEMBL19038 | — | — | 1 | 6.30 |
| CHEMBL275582 | — | — | 1 | 6.12 |
| CHEMBL19075 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18225 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL18225 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL279267 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL18578 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL276782 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL429068 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL277994 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL18627 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL19038 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL275582 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL19075 | — | Ki | > | 1600.0 | nM | - |