Assay Detail
Binding
CHEMBL818184
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Binding affinity against human trypsin
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
L-373,890, An achiral, noncovalent, subnanomolar thrombin inhibitor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.03 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL36397 | — | — | 1 | 6.85 |
| CHEMBL37836 | — | — | 1 | 6.46 |
| CHEMBL287614 | — | — | 1 | 6.24 |
| CHEMBL37035 | — | — | 1 | 6.05 |
| CHEMBL290947 | — | — | 1 | 6.03 |
| CHEMBL34306 | — | — | 1 | 5.82 |
| CHEMBL3085115 | — | — | 1 | 5.68 |
| CHEMBL424545 | — | — | 1 | 5.66 |
| CHEMBL115643 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL36397 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL37836 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL287614 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL37035 | — | Ki | = | 890.0 | nM | 6.05 |
| CHEMBL290947 | — | Ki | = | 940.0 | nM | 6.03 |
| CHEMBL34306 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL3085115 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL424545 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL115643 | — | Ki | = | 3000.0 | nM | 5.52 |