Assay Detail
Binding
CHEMBL818196
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for inhibition of Type II 5-alpha-reductase in Human Prostate Homogenates (HPH)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (CHEMBL1856) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Nonsteroidal inhibitors of human type I steroid 5-alpha-reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.55 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL138225 | EPRISTERIDE | 2.0 | 1 | 8.10 |
| CHEMBL24955 | BEXLOSTERIDE | 2.0 | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL138225 | EPRISTERIDE | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL24955 | BEXLOSTERIDE | IC50 | = | 10000.0 | nM | 5.00 |