Assay Detail
Functional
CHEMBL818201
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Blockade of synaptosomal sodium channels, inhibition of [14C]guanidinium ion flux into CHO cells expressing Type II sodium channel
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium channel protein type 2 subunit alpha (CHEMBL4187) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and characterization of N-(acenaphth-5-yl)-N'-(4-methoxynaphth-1-yl)guanidine as a glutamate release inhibitor and potential anti-ischemic agent
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.74 | 5.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28853 | — | — | 1 | 5.88 |
| CHEMBL307395 | — | — | 1 | 5.69 |
| CHEMBL744 | RILUZOLE | 4.0 | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28853 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL307395 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL744 | RILUZOLE | IC50 | = | 2200.0 | nM | 5.66 |