Assay Detail
Functional
CHEMBL818228
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Cytotoxicity was determined in Vero cells, relative to RVT
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Chlorocebus sabaeus |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
2('),3(')-didehydro-2('),3(')-dideoxynucleosides are degraded to furfuryl alcohol under acidic conditions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.03 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL123292 | CYCLOHEXIMIDE | 2.0 | 1 | 6.28 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 4.54 |
| CHEMBL219568 | GUANINE | 3.0 | 1 | 4.26 |
| CHEMBL38700 | ELVUCITABINE | 2.0 | 1 | - |
| CHEMBL993 | THYMINE | — | 1 | - |
| CHEMBL308187 | FURFURYL ALCOHOL | — | 1 | - |
| CHEMBL1463 | FLUCYTOSINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL123292 | CYCLOHEXIMIDE | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL219568 | GUANINE | IC50 | = | 54900.0 | nM | 4.26 |
| CHEMBL38700 | ELVUCITABINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL993 | THYMINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL308187 | FURFURYL ALCOHOL | IC50 | > | 100000.0 | nM | - |
| CHEMBL1463 | FLUCYTOSINE | IC50 | > | 100000.0 | nM | - |