Assay Detail
Binding
CHEMBL818263
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In vitro for inhibition of purified bovine trypsin.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Benzenesulfonamide derivatives of 2-substituted 4H-3,1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.69 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273264 | NAFAMOSTAT | 3.0 | 1 | 7.77 |
| CHEMBL165932 | — | — | 1 | 6.03 |
| CHEMBL166293 | — | — | 1 | 5.89 |
| CHEMBL168038 | — | — | 1 | 5.82 |
| CHEMBL355466 | — | — | 1 | 5.66 |
| CHEMBL165871 | — | — | 1 | 5.38 |
| CHEMBL167163 | — | — | 1 | 5.37 |
| CHEMBL354950 | — | — | 1 | 5.35 |
| CHEMBL353889 | — | — | 1 | 5.23 |
| CHEMBL166393 | — | — | 1 | 5.08 |
| CHEMBL168702 | — | — | 1 | 5.00 |
| CHEMBL354991 | — | — | 1 | - |
| CHEMBL166801 | — | — | 1 | - |
| CHEMBL354119 | — | — | 1 | - |
| CHEMBL10312 | — | — | 1 | - |
| CHEMBL165875 | — | — | 1 | - |
| CHEMBL169044 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273264 | NAFAMOSTAT | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL165932 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL166293 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL168038 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL355466 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL165871 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL167163 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL354950 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL353889 | — | IC50 | = | 5830.0 | nM | 5.23 |
| CHEMBL166393 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL168702 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL354991 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL166801 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL354119 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL10312 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL165875 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL169044 | — | IC50 | > | 100000.0 | nM | - |