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Assay Detail

CHEMBL818286

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Binding
Inhibitory activity against very late antigen-4 (VLA-4) using VCAM-Ig ligand.
ChEMBL ↗
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 6 — Multiple protein complex / RNA
Curated By Autocuration

Target

Integrin alpha-4/beta-1 (CHEMBL1907599) ↗
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Substituted N-(3,5-dichlorobenzenesulfonyl)-L-prolyl-phenylalanine analogues as potent VLA-4 antagonists.
Kopka IE, Young DN, Lin LS, Mumford RA, Magriotis PA, MacCoss M, Mills SG, Van Riper G, McCauley E, Egger LE, Kidambi U, Schmidt JA, Lyons K, Stearns R, Vincent S, Colletti A, Wang Z, Tong S, Wang J, Zheng S, Owens K, Levorse D, Hagmann WK.
Bioorg Med Chem Lett (2002) 12 : 637 -640
PubMed 11844689 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 46 8.77 9.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL41848 — — 1 9.66
CHEMBL418439 — — 1 9.57
CHEMBL348380 — — 1 9.52
CHEMBL348411 — — 1 9.48
CHEMBL295018 — — 1 9.47
CHEMBL289143 — — 1 9.43
CHEMBL348353 — — 1 9.36
CHEMBL160252 — — 1 9.32
CHEMBL345193 — — 1 9.32
CHEMBL330006 — — 1 9.30
CHEMBL345450 — — 1 9.23
CHEMBL432215 — — 1 9.19
CHEMBL155872 — — 1 9.17
CHEMBL346830 — — 1 9.17
CHEMBL351756 — — 1 9.14
CHEMBL160605 — — 1 9.10
CHEMBL347352 — — 1 9.07
CHEMBL348371 — — 1 9.07
CHEMBL158891 — — 1 9.07
CHEMBL345144 — — 1 9.07
CHEMBL348651 — — 1 9.05
CHEMBL345563 — — 1 9.04
CHEMBL423603 — — 1 9.04
CHEMBL349096 — — 1 9.00
CHEMBL348037 — — 1 9.00
CHEMBL347935 — — 1 8.96
CHEMBL158726 — — 1 8.92
CHEMBL423600 — — 1 8.89
CHEMBL346501 — — 1 8.88
CHEMBL347903 — — 1 8.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL41848 — IC50 = 0.22 nM 9.66
CHEMBL418439 — IC50 = 0.27 nM 9.57
CHEMBL348380 — IC50 = 0.3 nM 9.52
CHEMBL348411 — IC50 = 0.33 nM 9.48
CHEMBL295018 — IC50 = 0.34 nM 9.47
CHEMBL289143 — IC50 = 0.37 nM 9.43
CHEMBL348353 — IC50 = 0.44 nM 9.36
CHEMBL160252 — IC50 = 0.48 nM 9.32
CHEMBL345193 — IC50 = 0.48 nM 9.32
CHEMBL330006 — IC50 = 0.5 nM 9.30
CHEMBL345450 — IC50 = 0.59 nM 9.23
CHEMBL432215 — IC50 = 0.65 nM 9.19
CHEMBL346830 — IC50 = 0.67 nM 9.17
CHEMBL155872 — IC50 = 0.67 nM 9.17
CHEMBL351756 — IC50 = 0.73 nM 9.14
CHEMBL160605 — IC50 = 0.79 nM 9.10
CHEMBL347352 — IC50 = 0.86 nM 9.07
CHEMBL348371 — IC50 = 0.86 nM 9.07
CHEMBL158891 — IC50 = 0.85 nM 9.07
CHEMBL345144 — IC50 = 0.86 nM 9.07
CHEMBL348651 — IC50 = 0.9 nM 9.05
CHEMBL345563 — IC50 = 0.92 nM 9.04
CHEMBL423603 — IC50 = 0.92 nM 9.04
CHEMBL349096 — IC50 = 1.0 nM 9.00
CHEMBL348037 — IC50 = 0.99 nM 9.00
CHEMBL347935 — IC50 = 1.1 nM 8.96
CHEMBL158726 — IC50 = 1.2 nM 8.92
CHEMBL423600 — IC50 = 1.3 nM 8.89
CHEMBL346501 — IC50 = 1.31 nM 8.88
CHEMBL347903 — IC50 = 1.4 nM 8.85
CHEMBL422168 — IC50 = 1.6 nM 8.80
CHEMBL160887 — IC50 = 1.61 nM 8.79
CHEMBL160920 — IC50 = 1.7 nM 8.77
CHEMBL347037 — IC50 = 1.7 nM 8.77
CHEMBL160745 — IC50 = 1.8 nM 8.74
CHEMBL160568 — IC50 = 1.88 nM 8.73
CHEMBL156253 — IC50 = 2.3 nM 8.64
CHEMBL160171 — IC50 = 3.2 nM 8.49
CHEMBL347643 — IC50 = 3.6 nM 8.44
CHEMBL155800 — IC50 = 3.8 nM 8.42
CHEMBL345613 — IC50 = 3.9 nM 8.41
CHEMBL350913 — IC50 = 4.77 nM 8.32
CHEMBL345455 — IC50 = 26.5 nM 7.58
CHEMBL157147 — IC50 = 152.0 nM 6.82
CHEMBL433694 — IC50 = 2055.0 nM 5.69
CHEMBL352239 — IC50 = 28450.0 nM 4.55