Assay Detail
Binding
CHEMBL818331
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Urokinase-type plasminogen activator
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Urokinase-type plasminogen activator (CHEMBL3286) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.57 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70155 | — | — | 1 | 7.47 |
| CHEMBL71037 | — | — | 1 | 6.87 |
| CHEMBL70350 | — | — | 1 | 6.01 |
| CHEMBL69394 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70155 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL71037 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL70350 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL69394 | — | IC50 | = | 1210.0 | nM | 5.92 |