Assay Detail
Binding
CHEMBL818487
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Inhibition of 125I-fibrinogen binding to alpha IIb beta-3 integrin as inhibition of activated platelets
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis, evaluation and Tc-99m complexation of a hydrazinonicotinyl conjugate of a GP IIb/IIIa antagonist cyclic peptide for the detection of deep vein thrombosis
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.69 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL426408 | — | — | 1 | 8.30 |
| CHEMBL367058 | — | — | 1 | 8.22 |
| CHEMBL268350 | — | — | 1 | 8.10 |
| CHEMBL386693 | — | — | 1 | 8.05 |
| CHEMBL386694 | — | — | 1 | 7.96 |
| CHEMBL384194 | — | — | 1 | 7.89 |
| CHEMBL611722 | Hydrazinonicotinyl analogue | — | 1 | 7.89 |
| CHEMBL262549 | — | — | 1 | 7.80 |
| CHEMBL265628 | — | — | 1 | 5.02 |
| CHEMBL411753 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL426408 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL367058 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL268350 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL386693 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL386694 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL384194 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL611722 | Hydrazinonicotinyl analogue | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL262549 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL265628 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL411753 | — | IC50 | > | 1000.0 | nM | - |