Assay Detail
Binding
CHEMBL818574
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for human leukocyte elastase (HLE); Kreact/Kinact
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Inhibitors of human leukocyte elastase. 2.1 synthesis and sar of benzisothiazolinylmethyl aryl ethers
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 8.26 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3085439 | — | — | 1 | 9.40 |
| CHEMBL109234 | — | — | 1 | 9.10 |
| CHEMBL109411 | — | — | 1 | 8.80 |
| CHEMBL446371 | — | — | 1 | 8.66 |
| CHEMBL109488 | — | — | 1 | 8.46 |
| CHEMBL322104 | — | — | 1 | 8.40 |
| CHEMBL111770 | — | — | 1 | 8.00 |
| CHEMBL111174 | — | — | 1 | 7.87 |
| CHEMBL111419 | — | — | 1 | 7.47 |
| CHEMBL110267 | — | — | 1 | 7.38 |
| CHEMBL323411 | — | — | 1 | 7.29 |
| CHEMBL325756 | — | — | 1 | - |
| CHEMBL325098 | — | — | 1 | - |
| CHEMBL262709 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3085439 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL109234 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL109411 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL446371 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL109488 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL322104 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL111770 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL111174 | — | Ki | = | 13.6 | nM | 7.87 |
| CHEMBL111419 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL110267 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL323411 | — | Ki | = | 51.6 | nM | 7.29 |
| CHEMBL325756 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL325098 | — | Ki | > | 100.0 | nM | - |
| CHEMBL262709 | — | Ki | > | 100.0 | nM | - |