Assay Detail
Functional
CHEMBL818586
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 1 nM AVP-induced cAMP accumulation in cells expressing human vasopressin V2 receptor
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potent nonpeptide vasopressin receptor antagonists based on oxazino- and thiazinobenzodiazepine templates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 7.78 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93603 | — | — | 1 | 8.70 |
| CHEMBL432043 | — | — | 1 | 8.70 |
| CHEMBL329026 | — | — | 1 | 8.52 |
| CHEMBL543854 | — | — | 1 | 8.40 |
| CHEMBL314290 | — | — | 1 | 8.30 |
| CHEMBL327242 | — | — | 1 | 8.22 |
| CHEMBL330016 | — | — | 1 | 7.96 |
| CHEMBL94133 | — | — | 1 | 7.92 |
| CHEMBL328079 | — | — | 1 | 7.92 |
| CHEMBL329903 | — | — | 1 | 7.82 |
| CHEMBL93861 | — | — | 1 | 7.80 |
| CHEMBL539285 | — | — | 1 | 7.77 |
| CHEMBL330094 | — | — | 1 | 7.70 |
| CHEMBL327365 | — | — | 1 | 7.70 |
| CHEMBL93366 | — | — | 1 | 7.64 |
| CHEMBL49429 | LIXIVAPTAN | 3.0 | 1 | 7.64 |
| CHEMBL96255 | — | — | 1 | 7.40 |
| CHEMBL96731 | — | — | 1 | 7.40 |
| CHEMBL329141 | — | — | 1 | 7.16 |
| CHEMBL421180 | — | — | 1 | 7.16 |
| CHEMBL2093899 | — | — | 1 | 6.77 |
| CHEMBL330494 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93603 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL432043 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL329026 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL543854 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL314290 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL327242 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL330016 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL94133 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL328079 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL329903 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL93861 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL539285 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL330094 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL327365 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL93366 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL49429 | LIXIVAPTAN | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL96255 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL96731 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL329141 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL421180 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL2093899 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL330494 | — | Ki | = | 300.0 | nM | 6.52 |