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Assay Detail

CHEMBL818753

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity against alpha IIb beta-3 integrin in the presence of L-736622.
18
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 6 — Multiple protein complex / RNA
Curated By Autocuration

Target

Integrin alpha-IIb/beta-3 (CHEMBL2093869)
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Nonpeptide GPIIb/IIIa inhibitors. 10. Centrally constrained alpha-sulfonamides are potent inhibitors of platelet aggregation
Egbertson M, Hartman G, Gould R, Bednar B, Bednar R, Cook J, Gaul S, Holahan M, Libby L, Lynch J, Lynch R, Sitko G, Stranieri M, Vassallo L
Bioorg Med Chem Lett (1996) 6 : 2519 -2524
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 18 8.06 8.44

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL79294 1 8.44
CHEMBL298589 1 8.43
CHEMBL315065 2 8.36
CHEMBL313176 1 8.29
CHEMBL83015 1 8.22
CHEMBL82689 1 8.19
CHEMBL309742 1 8.19
CHEMBL84774 1 8.16
CHEMBL82862 1 8.13
CHEMBL311734 1 8.12
CHEMBL310294 1 8.12
CHEMBL314622 1 8.11
CHEMBL85064 1 7.92
CHEMBL916 TIROFIBAN 4.0 1 7.89
CHEMBL84259 1 7.82
CHEMBL82839 1 7.68
CHEMBL32960 1 7.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL79294 Kd = 3.6 nM 8.44
CHEMBL298589 Kd = 3.7 nM 8.43
CHEMBL315065 Kd = 4.4 nM 8.36
CHEMBL313176 Kd = 5.1 nM 8.29
CHEMBL83015 Kd = 6.0 nM 8.22
CHEMBL82689 Kd = 6.4 nM 8.19
CHEMBL309742 Kd = 6.4 nM 8.19
CHEMBL84774 Kd = 6.9 nM 8.16
CHEMBL82862 Kd = 7.4 nM 8.13
CHEMBL310294 Kd = 7.6 nM 8.12
CHEMBL311734 Kd = 7.5 nM 8.12
CHEMBL314622 Kd = 7.7 nM 8.11
CHEMBL315065 Kd = 8.8 nM 8.06
CHEMBL85064 Kd = 12.0 nM 7.92
CHEMBL916 TIROFIBAN Kd = 13.0 nM 7.89
CHEMBL84259 Kd = 15.0 nM 7.82
CHEMBL82839 Kd = 21.0 nM 7.68
CHEMBL32960 Kd = 100.0 nM 7.00