Assay Detail
Binding
CHEMBL818935
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Vascular endothelial growth factor receptor 2
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pyrazolo[3,4-d]pyrimidines containing an extended 3-substituent as potent inhibitors of Lck -- a selectivity insight.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.60 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45177 | — | — | 1 | 5.92 |
| CHEMBL44577 | — | — | 1 | 5.27 |
| CHEMBL45582 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45177 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL44577 | — | IC50 | = | 5320.0 | nM | 5.27 |
| CHEMBL45582 | — | IC50 | > | 50000.0 | nM | - |