Assay Detail
Functional
CHEMBL818943
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitumor activity against human melanoma UACC375 cell line.
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | UACC-375 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
2-[2'-(Dimethylamino)ethyl]-1,2-dihydro- 3H-dibenz[de,h]isoquinoline-1,3-diones with substituents at positions 4, 8, 9, 10, and 11. Synthesis, antitumor activity, and quantitative structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.83 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL144014 | — | — | 1 | 8.40 |
| CHEMBL147372 | — | — | 1 | 8.00 |
| CHEMBL146785 | — | — | 1 | 7.80 |
| CHEMBL343913 | — | — | 1 | 7.75 |
| CHEMBL356797 | — | — | 1 | 7.36 |
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 7.32 |
| CHEMBL422137 | — | — | 1 | 7.28 |
| CHEMBL149293 | — | — | 1 | 7.28 |
| CHEMBL148281 | — | — | 1 | 7.19 |
| CHEMBL290677 | AZONAFIDE | — | 1 | 7.15 |
| CHEMBL147576 | — | — | 1 | 7.11 |
| CHEMBL344310 | — | — | 1 | 7.11 |
| CHEMBL356785 | — | — | 1 | 7.09 |
| CHEMBL148344 | — | — | 1 | 7.05 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.95 |
| CHEMBL439812 | — | — | 1 | 6.79 |
| CHEMBL345020 | — | — | 1 | 6.75 |
| CHEMBL358993 | — | — | 1 | 6.74 |
| CHEMBL146559 | — | — | 1 | 6.57 |
| CHEMBL146037 | — | — | 1 | 6.48 |
| CHEMBL343852 | — | — | 1 | 6.41 |
| CHEMBL439632 | — | — | 1 | 6.27 |
| CHEMBL149184 | — | — | 1 | 6.21 |
| CHEMBL146516 | — | — | 1 | 5.92 |
| CHEMBL147428 | — | — | 1 | 5.73 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 5.69 |
| CHEMBL148229 | — | — | 1 | 5.69 |
| CHEMBL422843 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL144014 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL147372 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL146785 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL343913 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL356797 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL58 | MITOXANTRONE | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL422137 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL149293 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL148281 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL290677 | AZONAFIDE | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL147576 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL344310 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL356785 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL148344 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL439812 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL345020 | — | IC50 | = | 176.0 | nM | 6.75 |
| CHEMBL358993 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL146559 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL146037 | — | IC50 | = | 332.0 | nM | 6.48 |
| CHEMBL343852 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL439632 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL149184 | — | IC50 | = | 624.0 | nM | 6.21 |
| CHEMBL146516 | — | IC50 | = | 1215.0 | nM | 5.92 |
| CHEMBL147428 | — | IC50 | = | 1858.0 | nM | 5.73 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 2031.0 | nM | 5.69 |
| CHEMBL148229 | — | IC50 | = | 2056.0 | nM | 5.69 |
| CHEMBL422843 | — | IC50 | = | 7547.0 | nM | 5.12 |