Assay Detail
Functional
CHEMBL818944
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested against UACC375 human melanoma cancer cells by sulforhodamine B (SRB) assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Cancer cell lines |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
2-substituted 1,2-dihydro-3H-dibenz[de,h]isoquinoline-1,3-diones. A new class of antitumor agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.20 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL165018 | — | — | 1 | 7.41 |
| CHEMBL423257 | — | — | 1 | 7.23 |
| CHEMBL349402 | — | — | 1 | 7.17 |
| CHEMBL290677 | AZONAFIDE | — | 1 | 7.15 |
| CHEMBL166139 | — | — | 1 | 6.92 |
| CHEMBL348916 | — | — | 1 | 6.75 |
| CHEMBL166257 | — | — | 1 | 6.72 |
| CHEMBL351618 | — | — | 1 | 6.66 |
| CHEMBL165977 | — | — | 1 | 6.61 |
| CHEMBL166129 | — | — | 1 | 6.33 |
| CHEMBL165858 | — | — | 1 | 6.29 |
| CHEMBL434285 | — | — | 1 | 5.79 |
| CHEMBL166062 | — | — | 1 | 5.78 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 5.69 |
| CHEMBL165170 | — | — | 1 | 5.60 |
| CHEMBL163792 | — | — | 1 | 5.60 |
| CHEMBL351023 | — | — | 1 | 5.30 |
| CHEMBL350519 | — | — | 1 | 5.19 |
| CHEMBL164825 | — | — | 1 | 4.95 |
| CHEMBL166191 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL165018 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL423257 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL349402 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL290677 | AZONAFIDE | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL166139 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL348916 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL166257 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL351618 | — | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL165977 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL166129 | — | IC50 | = | 463.0 | nM | 6.33 |
| CHEMBL165858 | — | IC50 | = | 511.0 | nM | 6.29 |
| CHEMBL434285 | — | IC50 | = | 1622.0 | nM | 5.79 |
| CHEMBL166062 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 2031.0 | nM | 5.69 |
| CHEMBL165170 | — | IC50 | = | 2532.0 | nM | 5.60 |
| CHEMBL163792 | — | IC50 | = | 2493.0 | nM | 5.60 |
| CHEMBL351023 | — | IC50 | = | 4975.0 | nM | 5.30 |
| CHEMBL350519 | — | IC50 | = | 6443.0 | nM | 5.19 |
| CHEMBL164825 | — | IC50 | = | 11363.0 | nM | 4.95 |
| CHEMBL166191 | — | IC50 | = | 12032.0 | nM | 4.92 |