Assay Detail
Functional
CHEMBL818947
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against P induced IL-6 secretion in U-373 MG Astrocytoma cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U11 MG |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
3-Aryl-1,2-diacetamidopropane derivatives as novel and potent NK-1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.76 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL351274 | — | — | 1 | 8.92 |
| CHEMBL16192 | CP-96345 | — | 1 | 8.40 |
| CHEMBL42407 | LANEPITANT | 2.0 | 1 | 8.26 |
| CHEMBL352102 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL351274 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL16192 | CP-96345 | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL42407 | LANEPITANT | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL352102 | — | Ki | = | 3500.0 | nM | 5.46 |