Assay Detail
Functional
CHEMBL818976
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Evaluated for the inhibition of tubulin polymerization without pre-incubation
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bos taurus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Antitumor agents. 139. Synthesis and biological evaluation of thiocolchicine analogs 5,6-dihydro-6(S)-(acyloxy)- and 5,6-dihydro-6(S)-[(aroyloxy)methyl]-1,2,3-trimethoxy-9-(methylthio)-8H- cyclohepta[a]naphthalen-8-ones as novel cytotoxic and antimitotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.43 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL153629 | — | — | 1 | 5.55 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.50 |
| CHEMBL3085279 | — | — | 1 | 5.43 |
| CHEMBL291198 | — | — | 1 | 5.42 |
| CHEMBL357350 | — | — | 1 | 5.37 |
| CHEMBL18981 | THIOCOLCHICINE | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL153629 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3085279 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL291198 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL357350 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL18981 | THIOCOLCHICINE | IC50 | = | 4900.0 | nM | 5.31 |