Assay Detail
Functional
CHEMBL818978
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration inhibiting tubulin polymerization (ITP)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bos taurus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Antitumor agents. 196. Substituted 2-thienyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.13 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL132896 | — | — | 1 | 6.43 |
| CHEMBL15778 | — | — | 1 | 6.31 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 6.23 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 6.18 |
| CHEMBL49827 | — | — | 1 | 6.14 |
| CHEMBL130179 | — | — | 1 | 6.11 |
| CHEMBL130200 | — | — | 1 | 6.04 |
| CHEMBL423514 | — | — | 1 | 5.92 |
| CHEMBL49621 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL132896 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL15778 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL61 | PODOFILOX | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL49827 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL130179 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL130200 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL423514 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL49621 | — | IC50 | = | 1500.0 | nM | 5.82 |