Assay Detail
Binding
CHEMBL818986
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Tubulin polymerization by a 40 uM solution of compound; compound showed inhibition >50% at 40 uM
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Methoxy-substituted 3-formyl-2-phenylindoles inhibit tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.46 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL145872 | — | — | 1 | 5.82 |
| CHEMBL147438 | — | — | 1 | 5.75 |
| CHEMBL148029 | — | — | 1 | 5.75 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.72 |
| CHEMBL144222 | — | — | 1 | 5.48 |
| CHEMBL147487 | — | — | 1 | 5.40 |
| CHEMBL120152 | — | — | 1 | 5.05 |
| CHEMBL118314 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL145872 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL147438 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL148029 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL107 | COLCHICINE | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL144222 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL147487 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL120152 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL118314 | — | IC50 | = | 19000.0 | nM | 4.72 |