Assay Detail
Binding
CHEMBL819273
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Binding affinity towards human trypsin
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.15 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157417 | — | — | 1 | 8.47 |
| CHEMBL160489 | — | — | 1 | 8.19 |
| CHEMBL356016 | — | — | 1 | 7.82 |
| CHEMBL152854 | — | — | 1 | 7.80 |
| CHEMBL153611 | — | — | 1 | 7.68 |
| CHEMBL349323 | — | — | 1 | 7.58 |
| CHEMBL346825 | — | — | 1 | 7.57 |
| CHEMBL152274 | — | — | 1 | 7.25 |
| CHEMBL156924 | — | — | 1 | 7.22 |
| CHEMBL160575 | — | — | 1 | 7.01 |
| CHEMBL160958 | — | — | 1 | 6.72 |
| CHEMBL347606 | — | — | 1 | 6.66 |
| CHEMBL351755 | — | — | 1 | 6.58 |
| CHEMBL157299 | — | — | 1 | 6.58 |
| CHEMBL156505 | — | — | 1 | 6.41 |
| CHEMBL160515 | — | — | 1 | 6.11 |
| CHEMBL159204 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157417 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL160489 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL356016 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL152854 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL153611 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL349323 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL346825 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL152274 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL156924 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL160575 | — | Ki | = | 97.0 | nM | 7.01 |
| CHEMBL160958 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL347606 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL351755 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL157299 | — | Ki | = | 261.0 | nM | 6.58 |
| CHEMBL156505 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL160515 | — | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL159204 | — | Ki | = | 1100.0 | nM | 5.96 |